Question

Choose the correct match of laxative and its Mechanism of Action (MOA):

• A. (1)-(Q), (2)-(P), (3)-(R), (4)-(S)
• B. (1)-(Q), (2)-(R), (3)-(S), (4)-(P)
• C. (1)-(R), (2)-(Q), (3)-(P), (4)-(S)
• D. (1)-(Q), (2)-(R), (3)-(P), (4)-(S)

Hint:

Understanding laxative mechanisms helps in selecting appropriate therapy based on constipation etiology and patient condition.

Answer 1

The Correct Option is A

- Senna is a stimulant laxative (Q). It acts by stimulating the enteric nerves to increase peristalsis, promoting bowel movements.
- Lactulose is an osmotic purgative (P). It draws water into the colon, softening stools and increasing bowel movement frequency.
- Lubiprostone causes fecal softening (R) by activating chloride channels in the intestinal epithelium, increasing fluid secretion into the bowel.
- Prucalopride is a selective 5-HT₄ receptor agonist (S) that enhances colonic motility by stimulating serotonin receptors.
This classification aligns with the pharmacological mechanisms of these laxatives used in clinical practice.