Question

Which of the following is considered the gold standard for the diagnosis of multiple sclerosis?

• A. CT scan of the brain
• B. MRI of the brain and spinal cord
• C. Lumbar puncture for oligoclonal bands
• D. Visual evoked potentials

Hint:

Apply McDonald criteria: MRI is key for dissemination in space and time.

Answer 1

The Correct Option is B

Step 1: Understanding the question.
The question seeks the gold standard imaging or diagnostic tool for multiple sclerosis, which demonstrates dissemination of lesions in space and time.
Step 2: Analyzing the options.
(A) CT scan of the brain: Less sensitive for detecting MS lesions.
(B) MRI of the brain and spinal cord: Correct — It is the gold standard, often with gadolinium to identify active lesions.
(C) Lumbar puncture for oligoclonal bands: Supportive but not the gold standard.
(D) Visual evoked potentials: Useful for subclinical lesions but not primary diagnostic tool.
Step 3: Conclusion.
The correct answer is (B) MRI of the brain and spinal cord, as it is the gold standard for diagnosing multiple sclerosis.