Question

Which of the following cardiac biomarkers rises earliest after the onset of acute myocardial infarction?

• A. Creatine kinase-MB (CK-MB)
• B. Cardiac troponin T
• C. Myoglobin
• D. Lactate dehydrogenase (LDH)

Hint:

Myoglobin is useful for early rule-out of MI due to its rapid rise, though troponins are preferred for confirmation due to higher specificity.

Answer 1

The Correct Option is C

Step 1: Understanding the question.
The question focuses on the biomarker that elevates first following myocardial necrosis in acute myocardial infarction.
Step 2: Analyzing the options.
(A) Creatine kinase-MB (CK-MB): Rises 4-6 hours after onset, peaks at 18-24 hours.
(B) Cardiac troponin T: Highly specific, rises 3-6 hours after onset.
(C) Myoglobin: Correct — Small molecule released rapidly, rises within 1-3 hours.
(D) Lactate dehydrogenase (LDH): Rises later, around 24 hours.
Step 3: Conclusion.
The correct answer is (C) Myoglobin, the earliest rising biomarker after acute myocardial infarction.