Question

Which of the following is a cytokine inhibitor used as anti-inflammatory?

• A. \( \text{Nimesulide} \)
• B. \( \text{Abatacept} \)
• C. \( \text{Diclofenac} \)
• D. \( \text{Nabumetone} \)

Hint:

Cytokine inhibitors are crucial in managing autoimmune diseases by selectively blocking inflammatory pathways instead of broadly suppressing immunity.

Answer 1

The Correct Option is B

Abatacept is a fusion protein that inhibits T-cell activation by binding to CD80 and CD86, preventing their interaction with CD28. It is used as an immunosuppressive agent for treating inflammatory conditions such as rheumatoid arthritis. Unlike NSAIDs like diclofenac or nimesulide, which inhibit cyclooxygenase enzymes, abatacept directly modulates immune responses.