Question

Which of the following drug can be given in patients of primary pulmonary hypertension?

• A. Icatibant
• B. Bosentan
• C. Labetolol
• D. Sodium nitroprusside

Answer 1

The Correct Option is B

Primary pulmonary hypertension (PPH) is a condition characterized by high blood pressure in the pulmonary arteries, leading to increased strain on the heart. Selecting an appropriate treatment is crucial for managing this condition effectively.

Given the options:

• Icatibant
• Bosentan
• Labetolol
• Sodium nitroprusside

we need to identify which drug is suitable for patients with primary pulmonary hypertension.

Bosentan is the correct choice:

• Bosentan is an endothelin receptor antagonist, specifically used for treating pulmonary arterial hypertension (PAH) by reducing blood pressure in the pulmonary arteries.
• It works by blocking endothelin-1, a substance that causes blood vessels to constrict, thus helping to lower the resistance in the pulmonary vessels and improve heart function.

Considering the mechanism of each drug:

• Icatibant is a bradykinin receptor antagonist, mainly used for hereditary angioedema, not indicated for PPH.
• Labetolol is a beta-blocker used primarily for hypertension but not specifically beneficial for pulmonary vascular pressures.
• Sodium nitroprusside is a potent vasodilator used in hypertensive emergencies but is not typically used for long-term management of pulmonary hypertension.

Therefore, based on mechanism and its clinical indications, Bosentan is the appropriate choice for treating primary pulmonary hypertension.