The stability of a gene pool, as described by Hardy-Weinberg equilibrium, requires the following conditions:
- Large population (P) helps to minimize genetic drift.
- No net mutation (Q) ensures that no new alleles are introduced into the gene pool.
- No selection (S) ensures that all individuals have equal reproductive success, which helps maintain allele frequencies.
Thus, non-random mating (R) does not contribute to stability and can alter the gene pool. Hence, the correct answer is (D).