Question

Which of the following complementarity determining regions (CDRs) of antibodies is sequentially and conformationally the most variable?

• A. CDR1 of Light chain
• B. CDR3 of Light chain
• C. CDR1 of Heavy chain
• D. CDR3 of Heavy chain

Hint:

When learning about antibodies, focus on the variability in CDR3 regions for their antigen-binding diversity.

Answer 1

The Correct Option is D

CDR3 of the heavy chain is the most variable in both sequential and conformational terms. This variability plays a crucial role in the diversity of the antibody's antigen-binding specificity. CDRs are part of the variable region of the antibody that binds to the antigen, and CDR3 is the most critical in determining this specificity.