Question:
Which of the following complementarity determining regions (CDRs) of antibodies is sequentially and conformationally the most variable?
Which of the following complementarity determining regions (CDRs) of antibodies is sequentially and conformationally the most variable?
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When learning about antibodies, focus on the variability in CDR3 regions for their antigen-binding diversity.
Updated On: Jun 18, 2025
- CDR1 of Light chain
- CDR3 of Light chain
- CDR1 of Heavy chain
- CDR3 of Heavy chain
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The Correct Option is D
Solution and Explanation
CDR3 of the heavy chain is the most variable in both sequential and conformational terms. This variability plays a crucial role in the diversity of the antibody's antigen-binding specificity. CDRs are part of the variable region of the antibody that binds to the antigen, and CDR3 is the most critical in determining this specificity.
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