Question

Which of the following binds to the small ribosomal subunit (30S) and interferes with protein synthesis by causing misreading of the mRNA?

• A. Macrolides
• B. Aminoglycosides
• C. Lincosamines
• D. Quinolones

Hint:

Aminoglycosides target the 30S ribosomal subunit, causing mRNA misreading and disrupting protein synthesis.

Answer 1

The Correct Option is B

Step 1: Understanding the Action of Aminoglycosides 
Aminoglycosides bind to the 30S ribosomal subunit, causing misreading of the mRNA and inhibiting protein synthesis. 
Step 2: Evaluating the Options 
- Macrolides: Bind to the 50S subunit, inhibiting protein synthesis by preventing elongation. 
- Aminoglycosides: Correct, bind to the 30S subunit and cause misreading of the mRNA. 
- Lincosamines: Bind to the 50S subunit and inhibit protein synthesis, not by misreading. 
- Quinolones: Inhibit DNA gyrase, not directly involved in ribosomal binding. 
Step 3: Conclusion 
Aminoglycosides interfere with protein synthesis by causing misreading of mRNA.