Which compound will give Hoffmann bromamide a degradation reaction?
- Ar-CONH2
- Ar-NH2
- Ar-NO2
- Ar-CH2-NH2
The Correct Option is D
Solution and Explanation
The Hoffman bromamide degradation reaction is used to convert amides to primary amines. The amide will be treated with bromine in the presence of a base (NaOH) to produce a primary amine. RCONH₂ +Br₂+ 4NaOH → RNH₂ +Na₂CO₃ +2NaBr +2 H₂O , Ar-CH₂-NH₂ Will undergo Hoffman bromamide degradation and form the corresponding primary amine (RNH₂)
Top Questions on Amines
- Number of compounds which give reaction with Hinsberg's reagent is_______.
- An amine $(\text{X})$ is prepared by ammonolysis of benzyl chloride. On adding $p$-toluenesulphonyl chloride to it, the solution remains clear.Molar mass of the amine $(\text{X})$ formed is _____ $\text{g mol}^{-1}$.(Given molar mass in $\text{g mol}^{-1}$: $\text{C} = 12, \, \text{H} = 1, \, \text{O} = 16, \, \text{N} = 14$)
- X of enthanamine was subjected to reaction with \(NaNO_2/HCl\) followed by hydrolysis to liberate \(N_2\) and HCl. The HCl generated was completely neutralised by 0.2 moles of NaOH. X is ____ g.
- Number of amine compounds from the following giving solids which are soluble in NaOH upon reaction with Hinsberg's reagent is _____.
- Given below are two statements:
Statement (I) : All the following compounds react with p-toluenesulfonyl chloride.
$C_6H_5NH_2 \quad (C_6H_5)_2NH \quad (C_6H_5)_3N$
Statement (II) : Their products in the above reaction are soluble in aqueous NaOH.
In the light of the above statements, choose the correct answer from the options given below.
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Concepts Used:
Amines - Chemical Properties
There are many chemical properties of amines.
The primary and secondary amines, including several amine derivatives, have a direct impact on their properties due to the presence of hydrogen bonding. The compounds containing phosphorus have a lower boiling point and the compounds containing amines and alcohol have a higher boiling point. The structure of alkanols is immensely similar to that of amine except the presence of the hydroxyl group. In such a case, oxygen has a higher electronegativity than that of nitrogen, so alkanol compounds are more acidic in nature in comparison to the amines.
On account of the ability to form hydrogen bonds, the amines have tendencies of high solubility in water. The amine molecules such as Ethyl, diethyl, triethyl, and Methyl are gaseous in nature. Whereas, higher weight amines have a solid structure and alkyl amines have a liquid structure. There is an ammonia smell to gaseous amines and a fishy smell to liquid amines. The solubility of amines entirely depends upon the number of carbon atoms in the molecule.