Question

Which bacterial enzyme helps the survival of Helicobacter pylori in the stomach?

• A. \( \text{carbonic anhydrase} \)
• B. \( \text{urease} \)
• C. \( \beta\text{-lactamase} \)
• D. \( \text{transpeptidase} \)

Hint:

Urease inhibitors are being explored as potential therapeutic agents to disrupt Helicobacter pylori colonization.

Answer 1

The Correct Option is B

Helicobacter pylori survives in the acidic environment of the stomach by producing urease. Urease catalyzes the hydrolysis of urea into ammonia and carbon dioxide, creating an alkaline microenvironment. This neutralization of stomach acid allows H. pylori to colonize and persist, contributing to gastric disorders such as ulcers.