Question:

Which activity (the signal transduction pathway) of metformin is responsible for the inhibitory effect on glucose production by liver cells?

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AMPK acts as an energy sensor in cells, regulating metabolism to enhance glucose uptake and improve insulin sensitivity.
Updated On: Jun 8, 2025
  • \( \text{Activation of AMPK} \)
  • \( \text{Inhibition of hormone-sensitive lipase} \)
  • \( \text{Inhibition of mammalian target of rapamycin (mTOR)} \)
  • \( \text{Allosteric regulation by binding to a crucial section of the DNA that makes proteins needed for glucose uptake} \)
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The Correct Option is A

Solution and Explanation

Metformin exerts its glucose-lowering effect primarily through activation of AMP-activated protein kinase (AMPK). AMPK reduces hepatic gluconeogenesis, improving insulin sensitivity and decreasing glucose production by liver cells. This mechanism makes metformin a first-line drug in the management of type 2 diabetes.
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