For a circle with center \( (h, k) \) and radius \( r \), the equation is:
\[
(x - h)^2 + (y - k)^2 = r^2
\]
We are given the center \( (h, k) = (1, 2) \). To find the radius, use the distance formula between the center and the point \( (4, 6) \):
\[
r = \sqrt{(4 - 1)^2 + (6 - 2)^2} = \sqrt{9 + 16} = \sqrt{25} = 5
\]
Thus, the equation of the circle is:
\[
(x - 1)^2 + (y - 2)^2 = 25
\]
Expanding:
\[
(x^2 - 2x + 1) + (y^2 - 4y + 4) = 25
\]
\[
x^2 + y^2 - 2x - 4y + 5 = 25
\]
\[
x^2 + y^2 - 2x - 4y + 1 = 0
\]
Thus, the equation of the circle is \( x^2 + y^2 - 2x - 4y + 1 = 0 \).