Question

What is the mechanism of action of Tocilizumab?

• A. Inhibits binding of IL-1
• B. Inhibits binding of IL-6 to its receptor IL-6R
• C. TNF Alpha inhibition
• D. IL-18 inhibition

Answer 1

The Correct Option is B

The mechanism of action for Tocilizumab involves the inhibition of the binding of the cytokine Interleukin-6 (IL-6) to its receptor (IL-6R). This inhibition occurs through the specific interaction of Tocilizumab, a monoclonal antibody, with the IL-6 receptor, thereby preventing IL-6 from engaging with its receptor. As IL-6 is a key cytokine in immune response and inflammation, blocking its interaction with IL-6R reduces the inflammation and immune response associated with various diseases, such as rheumatoid arthritis.

Step-by-Step Explanation:

Identify the target of Tocilizumab: Tocilizumab is designed to target the IL-6 receptor (IL-6R).

Understand the cytokine pathway: IL-6 is a cytokine involved in acute phase reactions, inflammation, and the immune response.

Mechanism of Action: By binding to IL-6R, Tocilizumab prevents IL-6 from binding to its receptor, thereby hindering the signaling pathway that leads to inflammation and an immune response.

Clinical Significance: This action is crucial in conditions characterized by excessive IL-6 activity, such as rheumatoid arthritis, where Tocilizumab's action helps alleviate inflammation and disease symptoms.

Therefore, the correct answer is: Inhibits binding of IL-6 to its receptor IL-6R.