Question

DOC for Onychomycosis ?

• A. Terbinafine
• B. Fluconazole
• C. Nystatin
• D. Itraconazole

Answer 1

The Correct Option is A

Onychomycosis, commonly known as nail fungus, is a prevalent condition affecting the fingernails or toenails. In the treatment of onychomycosis, the choice of medication is crucial for effective results. The Drug of Choice (DOC) for onychomycosis is Terbinafine. This is because Terbinafine is highly effective against dermatophytes, which are the primary cause of onychomycosis. It works by inhibiting the enzyme squalene epoxidase, leading to a deficiency in ergosterol, an essential component of fungal cell membranes, thus disrupting cell function and growth.

Other options such as Fluconazole and Itraconazole are also used but are typically considered second-line treatments due to their broader spectrum and slightly different side effect profiles. Nystatin is not used for onychomycosis because it is primarily effective against yeast infections and not against dermatophytes.