Question

What is the histological difference between them in Ulcerative colitis & Crohn’s disease?

• A. Diffuse distribution of pseudopolyps
• B. Mucosal edema
• C. Crypt abscess
• D. Lymphoid aggregates in the mucosa

Answer 1

The Correct Option is C

In distinguishing ulcerative colitis from Crohn's disease histologically, one key feature is the presence of crypt abscesses. Here is a concise overview:

• Crypt Abscess: In ulcerative colitis, there is a characteristic finding of crypt abscesses. These are collections of neutrophils within the glandular lumens of the colon mucosa. It is a hallmark sign seen in ulcerative colitis but is less common and not a distinguishing feature in Crohn's disease.
• Diffuse Distribution of Pseudopolyps: These can occur due to the regeneration and healing process of mucosal ulcers. They can be seen in both ulcerative colitis and Crohn's disease and are not a distinguishing feature.
• Mucosal Edema: This can be present in both conditions and is indicative of inflammation; hence it's not specific for differentiating between them.
• Lymphoid Aggregates in the Mucosa: These are more commonly associated with Crohn's disease, often found throughout the entire bowel wall (transmural) and less specific in ulcerative colitis.

Therefore, when differentiating between ulcerative colitis and Crohn's disease histologically, identifying crypt abscesses would direct us more towards ulcerative colitis.