DNA gyrase, a type II topoisomerase, introduces negative supercoils into circular DNA. This reduces torsional strain and facilitates processes like replication and transcription by making the DNA more accessible to enzymes and proteins.
| List I | List II |
|---|---|
| (A) Histone erasers | (III) Deacetylases |
| (B) Histone readers | (IV) Bromodomain proteins |
| (C) Histone writers | (I) Methyltransferase |
| (D) DNA unwinding | (II) Topoisomerase |
Match List-I with List-II 

