True hermaphroditism, also known as ovotesticular disorder, is a condition where an individual has both ovarian and testicular tissue. This can manifest as an ovotestis, which is a single gonad with both ovarian and testicular tissue.
In terms of karyotype, 46 XX Ovotestis is the most common chromosomal arrangement associated with true hermaphroditism. Individuals with this condition often have one or more sets of sex chromosomes typically seen in the standard 46 XX or sometimes 46 XY configurations, but 46 XX is most frequently observed. This karyotype is significant because it reflects the presence of typically female chromosomal content alongside the development of both ovarian and testicular structures.
Given the options, the correct answer for the karyotype associated with true hermaphroditism is:
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