Question

Ticlopidine acts as:

• A. \( \text{Antagonist of P2Y}_{12} \text{ receptor} \)
• B. \( \text{Agonist of P2Y}_{12} \text{ receptor} \)
• C. \( \text{Agonist of GPIIb/IIIa receptor} \)
• D. \( \text{Antagonist of GPIIb/IIIa receptor} \)

Hint:

P2Y\(_{12}\) inhibitors prevent clot formation, reducing stroke and heart attack risk in high-risk patients.

Answer 1

The Correct Option is A

Ticlopidine is a P2Y\(_{12}\) receptor antagonist, inhibiting platelet aggregation by blocking ADP receptor activation. This prevents fibrinogen binding to GPIIb/IIIa receptors, reducing thrombus formation. It was historically used for stroke prevention, but newer drugs like clopidogrel have largely replaced it due to safety concerns.