Question

The reduced dose requirement of isoniazid is observed in patients who are:

• A. \( \text{Fast acetylator} \)
• B. \( \text{Slow acetylator} \)
• C. \( \text{G6PD deficient} \)
• D. \( \text{CYP450 induced} \)

Hint:

Genetic variations in drug metabolism influence dosage requirements and therapeutic outcomes.

Answer 1

The Correct Option is B

Isoniazid metabolism is influenced by N-acetyltransferase enzyme polymorphism. Patients with slow acetylation exhibit reduced drug clearance, leading to higher plasma concentrations and increased drug effects. Fast acetylators metabolize isoniazid rapidly, requiring higher doses for therapeutic efficacy.