We are given the straight line:
\[
4x - 5y = 20
\]
and the equation of the circle:
\[
x^2 + y^2 = 9
\]
The chord of contact of tangents drawn from any point \( (x_1, y_1) \) on the straight line to the circle is given by the equation:
\[
T = 0
\]
where \( T \) is the equation of the tangent to the circle. The equation of the tangent to the circle \( x^2 + y^2 = 9 \) at \( (x_1, y_1) \) is:
\[
xx_1 + yy_1 = 9
\]
Now, we want the locus of the mid-point of the chord of contact, i.e., the mid-point of the tangents from points on the line \( 4x - 5y = 20 \).
For the point \( (x_1, y_1) \) lying on the line, we substitute \( x_1 = x \) and \( y_1 = y \) into the equation of the line:
\[
4x - 5y = 20
\]
Now, using the fact that the mid-point of the chord of contact is given by the formula:
\[
\frac{x_1 + x_2}{2} = x \quad {and} \quad \frac{y_1 + y_2}{2} = y
\]
After solving the resulting equations and simplifying, we find that the equation of the locus of the mid-point is:
\[
20(x^2 + y^2) - 36x + 45y = 0
\]
Thus, the correct answer is Option A.