Question

The autoantibody associated with Hashimoto’s disease is:

• A. Thyroglobulin
• B. TSH Receptor
• C. Myelin Basic Protein
• D. Intrinsic Factors

Hint:

Hashimoto’s = Hypothyroidism = Anti-thyroglobulin and Anti-TPO antibodies. Graves’ = Hyperthyroidism = TSH receptor antibody.

Answer 1

The Correct Option is A

Step 1: Understanding Hashimoto’s thyroiditis.
Hashimoto’s disease is an autoimmune thyroid disorder in which the immune system attacks the thyroid gland, leading to hypothyroidism.
Step 2: Autoantibodies involved.
The most common antibodies found in Hashimoto’s are:
- Anti-thyroglobulin antibodies (Anti-Tg).
- Anti-thyroid peroxidase antibodies (Anti-TPO).
These antibodies damage the thyroid tissue and impair hormone production.
Step 3: Analyzing options.
- (A) Thyroglobulin: Correct, as anti-thyroglobulin antibodies are hallmark of Hashimoto’s.
- (B) TSH Receptor: Seen in Graves’ disease, not Hashimoto’s.
- (C) Myelin Basic Protein: Seen in multiple sclerosis, not Hashimoto’s.
- (D) Intrinsic Factor: Associated with pernicious anemia, not Hashimoto’s.
Final Answer:
\[ \boxed{\text{Thyroglobulin}} \]