Question

How much time it takes to manifest chronic rejection of transplant? Choose from the following options.

• A. Immediately
• B. Within Minutes
• C. Days to one week
• D. Months or years

Hint:

Hyperacute = minutes–hours, Acute = days–weeks, Chronic = months–years.

Answer 1

The Correct Option is D

Step 1: Understanding types of transplant rejection.
There are three main types of rejection: hyperacute, acute, and chronic.
- Hyperacute rejection occurs immediately within minutes to hours.
- Acute rejection occurs within days to weeks.
- Chronic rejection develops slowly over months to years.
Step 2: Pathophysiology of chronic rejection.
Chronic rejection involves progressive loss of graft function due to continuous immune-mediated injury, fibrosis, vascular thickening, and ischemia. This is not a sudden process but a slow, long-term deterioration.
Step 3: Identifying correct answer.
Since the question specifically asks for chronic rejection, the correct time frame is months or years.
Final Answer:
\[ \boxed{\text{Months or years}} \]