Question:
The antihypertensive drug with a tetrazole nucleus that binds to AT1 receptor with high affinity is ___.
The antihypertensive drug with a tetrazole nucleus that binds to AT1 receptor with high affinity is ___.
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Tetrazole rings in ARBs like valsartan mimic the carboxyl group of angiotensin II and improve receptor binding.
Updated On: Jun 16, 2025
- diazoxide
- valsartan
- talupidine
- fosinopril
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The Correct Option is B
Solution and Explanation
Valsartan is an angiotensin II receptor blocker (ARB) that contains a tetrazole ring, which enhances binding affinity to the AT1 receptor. This feature contributes to its efficacy in lowering blood pressure.
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