Question

Study the following and identify the correct option.
Statement I: The juxtaglomerular cells release renin in response to decreased blood pressure.
Statement II: Renin directly acts on distal convoluted tubule, leading to increased blood pressure.

• A. Both statements I and II are correct.
• B. Statement I is correct, but statement II is incorrect.
• C. Statement I is incorrect, but statement II is correct.
• D. Both statements I and II are incorrect.

Hint:

Juxtaglomerular cells release renin to initiate the RAAS, which increases blood pressure indirectly via angiotensin II, not by renin acting directly on the distal convoluted tubule.

Answer 1

The Correct Option is B

Let’s evaluate the statements using a checklist approach to determine their accuracy. For Statement I, we check if juxtaglomerular cells release renin when blood pressure decreases. These cells, located in the kidney near the glomerulus, indeed release renin in response to low blood pressure as part of the renin-angiotensin-aldosterone system (RAAS), which helps regulate blood pressure—Statement I is correct. For Statement II, we assess if renin directly acts on the distal convoluted tubule to increase blood pressure. Renin actually acts on angiotensinogen in the blood to produce angiotensin I, which is then converted to angiotensin II; angiotensin II affects blood vessels and the adrenal glands, not directly the distal convoluted tubule, and the tubule is more directly influenced by aldosterone later in the process—Statement II is incorrect. Conclusion: Statement I is correct, but Statement II is incorrect, matching option (2).