Question

Prominent biochemical features of Grave’s disease are

• A. Decreased ionized calcium in body fluids
• B. Decreased T₄ and T₃ in circulation
• C. Increased ionized calcium in body fluids
• D. Increaased T₄ and T₃ in circulation

Answer 1

The Correct Option is D

Grave's disease is an autoimmune disorder that primarily affects the thyroid gland, leading to its overactivity. Let's examine the options to determine the correct biochemical feature of Grave's disease.

1. Decreased ionized calcium in body fluids: This option is incorrect. Grave's disease primarily affects thyroid hormone levels, not calcium levels in the body.
2. Decreased T₄ and T₃ in circulation: This option is incorrect. In Grave's disease, the production and release of thyroid hormones T₄ (thyroxine) and T₃ (triiodothyronine) are increased, not decreased.
3. Increased ionized calcium in body fluids: Again, this is incorrect as Grave's disease is related to thyroid hormones, not directly affecting ionized calcium levels in the body fluids.
4. Increased T₄ and T₃ in circulation: This is the correct answer. In Grave's disease, the immune system mistakenly attacks the thyroid gland, causing it to produce excess thyroid hormones T₄ and T₃. This results in hyperthyroidism, characterized by increased levels of these hormones in circulation.

Therefore, the prominent biochemical feature of Grave's disease is the increased levels of T₄ and T₃ in circulation. This increase results in symptoms such as an accelerated metabolism, weight loss, rapid heartbeat, and nervousness. This feature distinguishes Grave's disease as a condition of hyperthyroidism.