Question

Nude mice is not resistant to xenograft due to absence of

• A. B cell
• B. T cell
• C. Both b and t cell
• D. None

Answer 1

The Correct Option is B

The question pertains to the specific immunological deficiencies observed in nude mice. These mice are characterized by a significant lack of thymus development, which directly impacts their immune system. Consequently, they experience a deficiency in T cells, a critical component of the adaptive immune response. This immunodeficiency renders them incapable of mounting a proper immune response against foreign tissues, such as those in xenograft experiments.

Here's the breakdown of options:

• B cell: While B cells are an essential element of the adaptive immune system, their presence doesn't compensate for the absence of T cells in nude mice.
• T cell: Correct. Nude mice lack a functional thymus and, therefore, are deficient in T cells, leading to their inability to reject xenografts.
• Both B and T cell: Incorrect. The primary and most impactful deficiency in nude mice is the lack of T cells; B cells are not inherently absent.
• None: Incorrect. There is indeed a deficiency impacting the immune function of nude mice.

Thus, the absence of T cells is the primary reason nude mice are not resistant to xenografts.