Question

If the plasma half-life of a drug is 1.386 h and the volume of distribution is 10 L, the total body clearance of the drug without any unit conversion will be _____.

• A. 5
• B. 20
• C. 13.86
• D. 6.93

Hint:

Use \( CL = \frac{0.693 \times V_d}{t_{1/2}} \) for drug clearance calculations.

Answer 1

The Correct Option is A

Clearance (CL) is calculated using the formula: \[ CL = \frac{0.693 \times V_d}{t_{1/2}} = \frac{0.693 \times 10}{1.386} = 5 \]