Question

MRP 2 associated with which of the following?

• A. Rotor syndrome
• B. Dubin-Johnson syndrome
• C. Crigler-Najjar syndrome
• D. Gilbert syndrome

Answer 1

The Correct Option is B

MRP2 (Multidrug Resistance-associated Protein 2) is closely associated with Dubin-Johnson syndrome. Dubin-Johnson syndrome is a rare, inherited liver disorder characterized by an increase in conjugated hyperbilirubinemia and a distinct black liver pigmentation. The underlying cause of this condition is the mutation in the ABCC2 gene, which encodes MRP2, responsible for transporting conjugated bilirubin and other organic anions from hepatocytes into bile. When there is a defect in MRP2 function, bilirubin accumulates in the liver leading to the characteristic symptoms of the syndrome. It remains asymptomatic with benign course but results in chronic jaundice that doesn't affect life expectancy. Thus, understanding the genetic basis and associated proteins like MRP2 is vital for diagnosing and recognizing Dubin-Johnson syndrome.