Question

MPTP, a prodrug, is converted to MPP\( ^+ \) by which enzyme?

• A. \( \text{MAO A} \)
• B. \( \text{MAO B} \)
• C. \( \text{DAO} \)
• D. \( \text{AChE} \)

Hint:

MPTP exposure led to significant insights into Parkinson’s disease, providing a model for neurodegeneration research.

Answer 1

The Correct Option is B

Monoamine oxidase B (MAO-B) converts MPTP into MPP\( ^+ \), a neurotoxic metabolite responsible for Parkinsonism symptoms. MPP\( ^+ \) selectively damages dopamine-producing neurons in the substantia nigra, mimicking Parkinson’s disease pathology. MAO-B inhibitors can help prevent MPTP-induced neurodegeneration.