Step 1: Causative agent.
Monkeypox is caused by the Monkeypox virus (MPXV), a member of the Orthopoxvirus genus in the family Poxviridae.
Step 2: Genome type.
All poxviruses are large, enveloped viruses with a linear double-stranded DNA genome.
Step 3: Eliminate incorrect options.
- Single-stranded DNA viruses: very small (e.g., parvoviruses), not poxviruses.
- RNA viruses: include orthomyxo-, paramyxo-, corona-, etc., not poxviruses.
Therefore, Monkeypox is caused by a double-stranded DNA virus.