Question

HPV is responsible mainly for:

• A. Ovarian Cancer
• B. Prostate Cancer
• C. Liver Cancer
• D. Cervical Cancer

Hint:

HPV-16 and HPV-18 together cause more than 70% of cervical cancers worldwide.

Answer 1

The Correct Option is D

Step 1: Understanding HPV.
Human Papillomavirus (HPV) is a DNA virus from the papillomavirus family. Certain high-risk strains like HPV-16 and HPV-18 are strongly associated with malignant transformation.
Step 2: Oncogenic mechanism.
HPV produces two oncogenic proteins, E6 and E7, which inactivate tumor suppressor proteins p53 and Rb respectively. This leads to uncontrolled cell proliferation and progression to cancer.
Step 3: Identifying the main cancer.
- HPV is responsible for almost all cases of cervical cancer worldwide.
- It can also cause other cancers such as anal, oropharyngeal, and penile cancers, but cervical cancer remains the primary disease associated.
Step 4: Excluding other options.
- (A) Ovarian cancer: Not linked to HPV.
- (B) Prostate cancer: No proven association with HPV.
- (C) Liver cancer: Commonly associated with Hepatitis B and C viruses, not HPV.
Final Answer:
\[ \boxed{\text{Cervical Cancer}} \]