Question

Match List-I with List-II 

Choose the correct answer from the options given below: 
 

• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (III), (C) - (II), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (II), (D) - (I)

Hint:

Associate key antibiotics with their source type. Penicillin \(\rightarrow\) *Penicillium* mold. Most "-mycin" antibiotics (like streptomycin, erythromycin) \(\rightarrow\) *Streptomyces* bacteria. Bacitracin \(\rightarrow\) *Bacillus*.

Answer 1

The Correct Option is D

Step 1: Understanding the Concept:
Many important antibiotics are natural products, secondary metabolites produced by microorganisms, primarily fungi and bacteria (especially from the phylum Actinobacteria). This question tests the knowledge of the specific microbial sources for several common antibiotics.
Step 2: Detailed Explanation:
(A) Penicillin G: This is one of the most famous antibiotics. It is produced by the filamentous fungus (mold) Penicillium chrysogenum. Therefore, (A) matches with (III).
(B) Gentamycin: This is an aminoglycoside antibiotic. It is produced by the bacterium Micromonospora purpurea. Therefore, (B) matches with (IV).
(C) Bacitracin: This is a polypeptide antibiotic used topically. It is produced by the bacterium Bacillus subtilis. Therefore, (C) matches with (II).
(D) Cycloheximide: This compound inhibits protein synthesis in eukaryotes and is often used in research. It is produced by the bacterium Streptomyces griseus (which is more famous for producing streptomycin). Therefore, (D) matches with (I).
Step 3: Final Answer:
The correct matching is: A-III, B-IV, C-II, D-I. This corresponds to option (4).