Question

Mode of action of nerve gas is:

• A. \( \text{Blocking of acetylcholinesterase} \)
• B. \( \text{Blocking of serotonergic action} \)
• C. \( \text{Blocking of cholinergic action} \)
• D. \( \text{Blocking of noradrenergic action} \)

Hint:

Nerve agents disrupt neurotransmission by preventing acetylcholine breakdown.

Answer 1

The Correct Option is A

Nerve gases such as sarin and VX act by irreversibly inhibiting acetylcholinesterase, leading to accumulation of acetylcholine at synapses, resulting in neuromuscular overstimulation. This leads to paralysis and respiratory failure, requiring rapid antidote administration.