Question

Mechanism of action of buspirone is?

• A. 5 HT1A partial agonism
• B. 5 HT1B antagonism
• C. 5 HT1B partial agonism
• D. 5 HT2C antagonism.

Answer 1

The Correct Option is A

Buspirone is an anxiolytic medication primarily used to treat generalized anxiety disorder (GAD). Its mechanism of action is associated with neurotransmitter modulation in the brain. Let's delve into how buspirone functions:

Buspirone acts as a partial agonist at the 5-HT1A receptors. These receptors are a subtype of serotonin receptors located in the brain, particularly abundant in regions associated with mood regulation, such as the hippocampus, cortex, and raphe nuclei. When buspirone binds to these receptors, it mimics serotonin's actions, albeit to a lesser extent, which helps modulate neurotransmitter activity to alleviate anxiety symptoms.

Choosing the correct mechanism of action from the options:

• 5 HT1A partial agonism: Correct, as buspirone acts as a partial agonist at 5-HT1A receptors.
• 5 HT1B antagonism: Incorrect, buspirone does not primarily act on 5-HT1B receptors.
• 5 HT1B partial agonism: Incorrect, this is not the primary mechanism of buspirone.
• 5 HT2C antagonism: Incorrect, buspirone does not primarily target 5-HT2C receptors.

Therefore, the most accurate description of buspirone's mechanism of action is 5 HT1A partial agonism.