Question

Match the LIST-I with LIST-II. \[ \begin{array}{|l|l|} \hline \textbf{LIST I} & \textbf{LIST II} \\ \hline A. \ \text{Franklin Stahl} & I. \ \beta\text{-form of DNA} \\ B. \ \text{Maurice Wilkins} & II. \ \text{Estimated absolute amount of each Base} \\ C. \ \text{Erwin Chargaff} & III. \ \text{Proposed two polynucleotide chain} \\ D. \ \text{Watson and Crick} & IV. \ \text{Individual strands of Duplexes are entirely heavy or light} \\ \hline \end{array} \]

• A. A - IV, B - II, C - III, D - I
• B. A - IV, B - II, C - I, D - III
• C. A - II, B - III, C - I, D - IV
• D. A - IV, B - I, C - II, D - III

Hint:

Remember:
- Franklin Stahl → Semi-conservative replication.
- Wilkins → Base estimates & X-ray diffraction.
- Chargaff → Base pairing rules.
- Watson & Crick → Double-helix B-DNA structure.

Answer 1

The Correct Option is A

Step 1: Franklin Stahl.
He worked along with Matthew Meselson in the Meselson–Stahl experiment demonstrating the semi-conservative replication of DNA. They used isotopes of nitrogen, showing that duplex DNA strands can be entirely heavy or light. Hence, Franklin Stahl → IV.
Step 2: Maurice Wilkins.
Wilkins, with Rosalind Franklin, worked on X-ray diffraction studies of DNA. He estimated the absolute amount of bases and contributed to crystallographic imaging. Hence, Maurice Wilkins → II.
Step 3: Erwin Chargaff.
He is known for Chargaff’s rules which state that in DNA, the amount of adenine equals thymine, and cytosine equals guanine. This laid the base-pairing rule and helped deduce DNA’s structure. His work supports two polynucleotide chains with complementary bases. Hence, Erwin Chargaff → III.
Step 4: Watson and Crick.
They proposed the double-helix model of DNA, with the B-form being the most stable under physiological conditions. Hence, Watson and Crick → I.
Final Matching:
A - IV, B - II, C - III, D - I
\[ \boxed{\text{Correct option is (1)}} \]