Question

Match List I with List II

	List I-Mechanism of action		List II-Drugs
A	DPP4 inhibitors	I	Metformin
B	KATP Channel blocker	II	Pioglitazone
C	PPAR activator	III	Glimepiride
D	AMP Activator	IV	Teneligliptin
E	-	V	α glucosidase inhibitors

Choose the correct answer from the options given below:

• A. A ‐II , B ‐V , C ‐III , D ‐IV
• B. A ‐ II, B ‐ III, C ‐IV , D ‐I
• C. A ‐IV , B ‐III , C ‐II , D ‐I
• D. A ‐IV, B ‐ I, C ‐V , D ‐III

Answer 1

The Correct Option is C

To solve this question, we need to match the mechanisms of action (List I) with the corresponding drugs (List II). We will go through each mechanism and identify the related drug: 

1. DPP4 inhibitors: DPP4 (Dipeptidyl Peptidase 4) inhibitors are a class of oral hypoglycemics that block DPP4, an enzyme that deactivates incretin hormones. By inhibiting DPP4, these drugs increase insulin release and decrease glucagon levels. The drug that matches with this mechanism is Teneligliptin. Thus, A matches with IV.
2. K_ATP Channel blocker: K_ATP channels are critical in insulin secretion. Blocking these channels helps to stimulate insulin release from the pancreas. Glimepiride is a well-known drug that acts as a K_ATP channel blocker. Hence, B matches with III.
3. PPAR activator: PPAR (Peroxisome Proliferator-Activated Receptor) activators affect the regulation of glucose and lipid metabolism. Pioglitazone is a thiazolidinedione that activates PPAR-gamma. Therefore, C matches with II.
4. AMP Activator: AMP (Adenosine Monophosphate) activators work by increasing AMP levels, which enhances insulin sensitivity and decreases hepatic glucose production. Metformin is best known for this action. Thus, D matches with I.

Thus, the correct matching is:

A	-	IV	Teneligliptin
B	-	III	Glimepiride
C	-	II	Pioglitazone
D	-	I	Metformin

The correct answer is therefore: A ‐IV, B ‐III, C ‐II, D ‐I.