Question

Match List I with List II

List I		List II
A	α –I antitrypsin	I	Cotton bollworm
B	Cry IAb	II	ADA deficiency
C	Cry IAc	III	Emphysema
D	Enzyme replacement therapy	IV	Corn borer

Choose the correct answer from the options given below:

• A. A-II, B-I, C-IV, D-III
• B. A-III, B-I, C-II, D-IV
• C. A-III, B-IV, C-I, D-II
• D. A-II, B-IV, C-I, D-III

Answer 1

The Correct Option is C

Step 1: Understanding the terms and their functions:

A. $\alpha$-1 antitrypsin: 
The $\alpha$-1 antitrypsin protein is a protective enzyme that inhibits the activity of enzymes like elastase, which can damage lung tissues. A deficiency in $\alpha$-1 antitrypsin causes emphysema, a condition where the lung tissue is damaged, leading to breathing problems. This deficiency leads to the overactive breakdown of lung tissue, causing emphysema and other respiratory issues. 
Match: A-III (Emphysema is caused by the deficiency of $\alpha$-1 antitrypsin).

B. Cry IAb: 
Cry IAb is a toxin derived from the bacterium *Bacillus thuringiensis* (Bt). This toxin is used as a biopesticide and is particularly effective in controlling the cotton bollworm, a pest that damages cotton crops. Cry IAb works by disrupting the digestive system of the pest, leading to its death. 
Match: B-IV (Cry IAb is used to control Cotton bollworm).

C. Cry IA:c: 
This is another toxin produced by *Bacillus thuringiensis* but is specifically effective against the corn borer, a major pest that affects maize (corn). The toxin works similarly to Cry IAb, disrupting the pest’s digestive system and killing it. 
Match: C-I (Cry IA:c is used to control Corn borer).

D. Enzyme replacement therapy: 
Enzyme replacement therapy (ERT) is used in the treatment of diseases like ADA (Adenosine deaminase) deficiency. ADA deficiency leads to severe combined immunodeficiency (SCID), where the immune system does not function properly. ERT involves administering the missing enzyme to help restore immune function in patients with ADA deficiency. 
Match: D-II (Enzyme replacement therapy is used to treat ADA deficiency).

Step 2: Conclusion:

The correct matches are as follows:

• A - III: $\alpha$-1 antitrypsin deficiency causes emphysema.
• B - IV: Cry IAb is used to control the Cotton bollworm.
• C - I: Cry IA:c is used to control the Corn borer.
• D - II: Enzyme replacement therapy is used to treat ADA deficiency.

Answer: The correct answer is (3) A-III, B-IV, C-I, D-II.

Answer 2

To solve this problem, we need to correctly match the items in List I with the corresponding items in List II based on their biological relationships or applications.

Here are the logical steps for each matching:

• A-III: α –I antitrypsin is related to emphysema. This protein protects the lungs from damage caused by enzyme activity.
• B-IV: Cry IAb is effective against corn borers and is a type of Bt toxin used in genetically modified crops.
• C-I: Cry IAc targets cotton bollworms, another Bt toxin used in pest-resistant crops.
• D-II: Enzyme replacement therapy is a treatment method used for conditions like ADA deficiency, where the body lacks certain enzymes.

Following this analysis, the correct matching is:

A-III, B-IV, C-I, D-II