“Leçon” is a feminine singular noun.
In the first blank, we need an interrogative adjective because “leçon” is a noun and is directly following.
So the correct form of “quel” is quelle (feminine singular).
Quelle leçon a-t-elle comprise ? (Which lesson did she understand?)
In the second blank, we are not repeating the noun — instead, we are referring back to “leçon” in a pronominal form.
Thus, we use laquelle, which is the feminine singular form of “lequel.”
Laquelle lui paraît difficile ? (Which one seems difficult to her?)
Final sentence: Quelle leçon a-t-elle comprise et laquelle lui paraît difficile ?