Question

Inhibition of peptidoglycan cross linking is the target of _______

• A. \( \text{Sulfadoxine} \)
• B. \( \text{Sulbactam} \)
• C. \( \text{Ceftriaxone} \)
• D. \( \text{Cilastatin} \)

Hint:

Think of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems) as cell wall synthesis inhibitors targeting peptidoglycans.

Answer 1

The Correct Option is C

Ceftriaxone is a cephalosporin antibiotic, and cephalosporins are a class of beta-lactam antibiotics that inhibit bacterial cell wall synthesis by interfering with the transpeptidation reaction involved in the cross-linking of peptidoglycans. Peptidoglycan is a crucial component of the bacterial cell wall, providing structural integrity. Inhibition of its cross-linking leads to a weakened cell wall and bacterial cell death. Sulfadoxine is a sulfonamide antibiotic that inhibits folate synthesis. Sulbactam is a beta-lactamase inhibitor. Cilastatin is a renal dehydropeptidase inhibitor used to prevent the metabolism of imipenem.