
1. Perform a cross between two sickle cell carriers. What ratio is obtained between carrier, disease free and diseased individuals in F1 progeny? Name the nitrogenous base substituted, in the haemoglobin molecule in this disease.
2. Explain the difference in inheritance pattern of flower colour in garden pea plant and snap-dragon plant with the help of monohybrid crosses.
OR,
Explain with the help of well-labelled diagrams how lac operon operates in E. coli :
1. In presence of an inducer.
2. In absence of an inducer.
Study the pedigree chart given below, showing the inheritance pattern of blood group in a family:

Answer the following questions:
(a) Give the possible genotypes of individual 1 and 2.
(b) Which antigen or antigens will be present on the plasma membranes of the R.B.Cs of individuals ‘5’ and ‘8’?
The sequence of nitrogenous bases in a segment of a coding strand of DNA is
5' – AATGCTAGGCAC – 3'. Choose the option that shows the correct sequence of nitrogenous bases in the mRNA transcribed by the DNA.

A ladder of fixed length \( h \) is to be placed along the wall such that it is free to move along the height of the wall.
Based upon the above information, answer the following questions:
(iii) (b) If the foot of the ladder, whose length is 5 m, is being pulled towards the wall such that the rate of decrease of distance \( y \) is \( 2 \, \text{m/s} \), then at what rate is the height on the wall \( x \) increasing when the foot of the ladder is 3 m away from the wall?