Question

In Wilson’s disease, there is less urinary excretion of:

• A. Phosphorus
• B. Methyl- Histidine
• C. Phosphotyrosine
• D. Serine

Answer 1

The Correct Option is B

Wilson's disease is a genetic disorder in which excess copper builds up in the body. This leads to defective copper metabolism, primarily affecting organs such as the liver and brain. One of the biochemical manifestations of Wilson’s disease is the alteration in urinary excretion levels of various metabolites.

In individuals with Wilson's disease, the urinary excretion of Methyl- Histidine decreases. This is due to impairment in specific metabolic processes linked to copper dysregulation, affecting amino acids and their derivatives.

Thus, in the context of Wilson’s disease, the metabolite with reduced urinary excretion is Methyl- Histidine.