Question

_____ is a protein marker which can be detected within three hours of acute ischemic kidney injury from patient’s urine.

• A. N-acetyl-β-D-glucose aminidase
• B. Gluthione-S-transferase
• C. Neutrophil gelatinase associated lipocalin
• D. γ-glutamyl transpeptidase

Answer 1

The Correct Option is A

Acute ischemic kidney injury can result in early detectable changes within the kidney's physiology, and certain protein markers can serve as indicators for such injuries. Among the given options, N-acetyl-β-D-glucose aminidase (NAG) is a well-known urinary enzyme that acts as a sensitive early indicator of kidney tubular damage, including ischemic kidney injury.

Explanation:

1. N-acetyl-β-D-glucose aminidase: This is a lysosomal enzyme found in renal proximal tubular cells. When kidney damage occurs, these cells release NAG into the urine. Its presence can be detected as early as three hours after kidney injury, making it a practical early marker.
2. Gluthione-S-transferase: While this enzyme is involved in detoxification processes and present in the liver and other tissues, it is not typically used as an early marker for acute ischemic kidney injury.
3. Neutrophil gelatinase associated lipocalin (NGAL): Although NGAL is a sensitive marker for acute kidney injury, it is more commonly associated with longer-term injury and inflammation, not specifically acute ischemic injury within three hours.
4. γ-glutamyl transpeptidase: This enzyme is indicative of liver dysfunction and not directly related to acute ischemic kidney damage detection.

Therefore, the correct answer is N-acetyl-β-D-glucose aminidase.