Question

A 10 year old presents with edema and anasarca. A diagnosis of minimal change disease is made. Which of the following is true about this condition?

• A. Light microscopy shows effacement of podocytes
• B. Good response to steroids
• C. Most common in adults
• D. Non selective proteinuria

Answer 1

The Correct Option is B

The question presents a scenario involving a 10-year-old patient diagnosed with minimal change disease (MCD). We are tasked with identifying the correct statement about this condition from the given options:

1.	Light microscopy shows effacement of podocytes
2.	Good response to steroids
3.	Most common in adults
4.	Non-selective proteinuria

Now, let's evaluate each option:

1. Light microscopy shows effacement of podocytes: This statement is incorrect in the context of minimal change disease because light microscopy typically appears normal. Effacement of podocytes is detected by electron microscopy, not light microscopy.
2. Good response to steroids: This statement is correct. Minimal change disease in children is characterized by a very good response to corticosteroid therapy, which often leads to rapid improvement of symptoms.
3. Most common in adults: This statement is incorrect. Minimal change disease is most common in children, not adults.
4. Non-selective proteinuria: This is incorrect as well. Patients with minimal change disease typically have selective proteinuria, with albumin being the primary protein in the urine.

Therefore, the correct option is: Good response to steroids.