Question

In a microarray experiment, the typical p-value for a reliable analysis of differentially gene expression is:

• A. 0.05
• B. 0.1
• C. 1.0
• D. 1.5

Hint:

A p-value of 0.05 is commonly used to determine statistical significance in gene expression studies.

Answer 1

The Correct Option is A

Step 1: Understanding p-value in Microarray Analysis 
In microarray experiments, the p-value is used to determine the statistical significance of gene expression differences. A p-value of 0.05 is typically considered the threshold for significance in most experiments. 
Step 2: Evaluating the Options 
- 0.05: Correct, this is the commonly accepted p-value threshold for determining significant differential expression. 
- 0.1: A higher threshold, used in some exploratory analyses, but not standard. 
- 1.0: Not used in significance testing; indicates no statistical difference. 
- 1.5: Not a p-value but a fold change, and not applicable here. 
Step 3: Conclusion 
A p-value of 0.05 is typically used for reliable analysis of differential gene expression in microarray experiments.