Question

IL- 1 activated by:

• A. Capsase 1
• B. Capsase 3
• C. Capsase 8
• D. Capsase 5

Answer 1

The Correct Option is A

In pathology, the activation of interleukin-1 (IL-1) is a crucial process in the inflammatory response. The enzyme responsible for converting pro-IL-1β, an inactive precursor, to its active form IL-1β is critical in this process. This activation is carried out by a specific caspase.

Caspase 1, also known as interleukin-1 converting enzyme (ICE), is the enzyme that activates IL-1. This enzyme cleaves the inactive precursor pro-IL-1β to produce the active cytokine IL-1β, which is a key mediator of inflammation and is involved in various cellular activities, including cell proliferation, differentiation, and apoptosis.

Let's briefly compare the roles of the other options:

• Caspase 3: Primarily known for its role in the execution phase of cell apoptosis, not involved in activating IL-1.
• Caspase 8: Involved in the extrinsic pathway of apoptosis, particularly in the signaling cascade that leads to cell death.
• Caspase 5: Associated with the inflammatory process but does not directly activate IL-1.

Therefore, the correct answer for the activation of IL-1 is Caspase 1.