Question

Choose the correct statement regarding the telomerase theory of aging

• A. Telomere stability is associated with aging
• B. Abnormal telomerase activation is associated with aging
• C. Decreased telomere length is associated with aging
• D. Increased telomere length is associated with aging

Answer 1

The Correct Option is C

The correct statement regarding the telomerase theory of aging is: Decreased telomere length is associated with aging.

Telomeres are repetitive nucleotide sequences at the ends of chromosomes, which protect them from degradation. During cell division, telomeres shorten, and as they reach a critically short length, the cell enters a state of senescence or apoptosis, contributing to the aging process.

Telomerase is an enzyme that can extend telomeres by adding nucleotide sequences, thus potentially counteracting the shortening process. However, in most somatic cells, telomerase activity is low or absent, leading to the progressive shortening of telomeres over time. This reduction in telomere length is associated with aging and age-related diseases.

Among the options given, Decreased telomere length is associated with aging accurately reflects the understanding of the role of telomeres and telomerase in the aging process.