For the first equation \(\frac{2}{\sqrt{x}} = 2\), squaring both sides gives:
\[
\sqrt{x} = 1 \quad \Rightarrow \quad x = 4
\]
For the second equation \(\frac{4}{\sqrt{y}} = -1\), squaring both sides gives:
\[
\sqrt{y} = -4 \quad \Rightarrow \quad y = 9
\]
Thus, the correct answer is \(x = 4\) and \(y = 9\).