Direction ratios of line joining $(4,3,-5)$ and $(-2,1,-8)$ are:
$a = -6,\ b = -2,\ c = -3$
Then $P = (-6, -6, -6)$
Now check which plane this satisfies.
Substitute into each:
Only $x + y - 2z = -6 -6 -2(-6) = -12 +12 = 0$
So, this is the correct plane.