Step 1: Understanding Hypothyroidism
Hypothyroidism is a medical condition in which the thyroid gland fails to produce enough thyroid hormones, particularly thyroxine (T4). This leads to a slow-down of the body’s metabolism and can cause fatigue, weight gain, and sensitivity to cold, among other symptoms.
Step 2: Role of Iodine in Thyroid Function
Iodine is a crucial mineral required for the synthesis of thyroid hormones. A deficiency of iodine in the diet prevents the thyroid gland from producing sufficient hormones, leading to hypothyroidism. This is particularly common in regions where iodine-rich foods are scarce.
Step 3: Thyroid Gland Enlargement (Goitre)
When iodine levels are low, the thyroid gland tries to compensate by enlarging, a condition known as goitre. This enlargement is a physical sign that the gland is underactive and is trying to trap more iodine from the bloodstream. Hence, enlargement of the thyroid gland is both a symptom and a consequence of hypothyroidism.
Step 4: Incorrect Options
Option A is incorrect because a high level of iodine typically does not cause hypothyroidism; in fact, excessive iodine can sometimes lead to hyperthyroidism or thyroiditis.
Option D is also incorrect because increased levels of thyroxine are associated with hyperthyroidism, not hypo-thyroidism.
Step 5: Conclusion
The correct options are B and C. Hypothyroidism is caused by low iodine levels in the diet and often results in enlargement of the thyroid gland (goitre) as a compensatory mechanism.