Question

Hypertension with peripheral edema & CKD

• A. Aliskiren
• B. Chlorthalidone
• C. Prazosin
• D. Beta blocker

Answer 1

The Correct Option is B

When considering treatment options for a patient with hypertension and peripheral edema in the context of chronic kidney disease (CKD), it is essential to choose a medication that addresses both conditions effectively while minimizing potential side effects exacerbating CKD. Here's an analysis of the options:

• Aliskiren: A direct renin inhibitor, not typically first-line for concurrent CKD.
• Chlorthalidone: A thiazide-like diuretic effective in reducing blood pressure and alleviating peripheral edema, suitable for CKD management.
• Prazosin: Primarily an alpha-blocker used for hypertension but isn't the best choice for managing edema or CKD.
• Beta blocker: Can manage hypertension but is less effective in treating edema and may have contraindications in certain CKD stages.

Optimal selection: Chlorthalidone due to its dual efficacy in managing hypertension and peripheral edema, particularly suitable in CKD management as it provides favorable outcomes without undue renal function compromise.